Ext. 2626

fgonzales@yachaytech.edu.ec

Short Bio

Dr. Gonzales-Zubiate obtained a bachelor degree in Biology at Federico Villarreal University, Peru. He did his master and doctoral studies in Biochemistry studying ribosomal RNA processing in the yeast Saccharomyces cerevisiae at University of São Paulo, Brazil. Years later, being a postdoc at the University of California – Los involved in the maturation of mRNAs and their transport to the cytoplasm. Back in Brazil, he started a postdoc at the University of São Paulo developing the research project “Biochemical and Structural Characterization of Yeast Exosome Interactions with regulatory proteins of its activity”. 

At the present time, he is Lecturer and Research Professor at Yachay Tech University, he also holds the position of director of Postgraduate Programs at School of Biological Sciences and Engineering.

Research Interests:

• Mechanisms of nucleus/cytoplasm transport in the cell.
• Ribosomal RNA processing, ribosome biogenesis, mRNA transport and maturation.
• Differential gene expression.
• Yeast-based biosensors.
• iGEM International Competition of Synthetic Biology.
• Protein folding

Selected Publications:

Castillo, K., Arias, J., Gonzales-Zubiate, F.A. (2023). Upgrading Non-Conventional Yeasts into Valuable Biofactories in the Book “Yeasts – New Perspectives” (ISBN 978-1-83768-320-8). Edited by Dr. Miguel Fernández-Niño. In press.

Lincopan, N., Maturrano, L., Luna, L., Muñoz, M., Fuentes-Castillo, D., Gonzales-Zubiate, F.A., Vignoli, R., Di Conza, J., Gutkind, G. (2023).  WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a Post-Pandemic World in the Book “Trending topics in Escherichia coli Research – The Latin American perspective”. Edited by Dr. Alfredo Torres. In press.

Gómez-Castillo, N.Y., Cajilima-Cardenaz, P.E., Zhinin-Vera, L., Maldonado-Cuascota, B., León Domínguez, D., Pineda-Molina, G., Hidalgo-Parra, A.A., Gonzales-Zubiate, F.A. (2022). A Machine Learning Approach for Blood Glucose Level Prediction Using a LSTM Network. Communications in Computer and Information Science. Volume 1532 CCIS, Pages 99 – 113.

https://doi.org/10.1007/978-3-030-99170-8_8

Mollocana-Lara, E.C., Ni, M., Agathos, S.N., Gonzales-Zubiate, F.A. (2021). The Infinite Possibilities of RNA Therapeutics. Journal of Industrial Microbiology and Biotechnology, 2021, kuab063. https://doi.org/10.1093/jimb/kuab063   

Scopus Q2, Impact Factor: 3,346.

Chang, O., Gonzales-Zubiate, F.A., Zhinin-Vera, L., Valencia-Ramos, R., Pineda, I., Diaz-Barrios, A. (2021). A Protein Folding Robot Driven by a Self-taught Agent. Biosystems, Volume 201, 2021, 104315. https://doi.org/10.1016/j.biosystems.2020.104315   

Scopus Q2, Impact Factor: 1,973.

Rech, B., and Gonzales-Zubiate, F.A. (2020). Mechanisms of Nuclear Transport in the cell: RNA exosome in Saccharomyces cerevisiae. Bionatura 5 (4), 1423-1426.

http://dx.doi.org/10.21931/RB/2020.05.04.25   

Q4 Scopus.

Okuda, E.K., Gonzales-Zubiate, F.A., Gadal, O., Oliveira, C.C. (2020). Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function. Journal of Biological Chemistry, 295 (32), 11195-11213. http://doi.org/10.1074/jbc.RA120.013589

Scopus Q1, Impact Factor: 5,157.

Portillo, R.T.V., Uscata, B.A., Gonzales-Zubiate, F.A., Medina, K.J., Sevillano, O.R., Ramos-Sanchez, E.M. (2020). Pruebas rápidas para COVID-19, la mejor alternativa para Ecuador. Bionatura 5 (3), 1280-1283. http://dx.doi.org/10.21931/RB/2020.05.03.21   

Q4 Scopus.

Mollocana-Lara, E.C., and Gonzales-Zubiate, F.A. (2020). Control of pesticides in Ecuador: An underrated problem? Bionatura 5 (3), 1257-1263. http://dx.doi.org/10.21931/RB/2020.05.03.17   Q4 Scopus.

Jacome, M.P.O., and Gonzales-Zubiate, F.A. (2019). How to stop the spreading of super bacteria?  Brasil Para Todos – Revista Internacional v.7, n.1, 2019. https://ojs.eniac.com.br/index.php/Anais_Sem_Int_Etn_Racial/index  https://ojs.eniac.com.br/index.php/Anais_Sem_Int_Etn_Racial/article/view/615

Gonzales-Zubiate, F.A., Cunha, J.P.C., Oliveira, C.C. (2017). Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae. Journal of Biological Chemistry JBC Jul 21; 292(29):12267-12284. Epub 2017 May 24 2017.

http://doi.org/10.1074/jbc.M116.772376   

Scopus Q1, Impact Factor: 5,157.

Miguel, R.B., Petersen, P.A.D., Gonzales-Zubiate, F.A., Oliveira, C.C., Kumar, N., Do Nascimento, R.R., Petrilli, H.M., Da Costa Ferreira, A.M. (2015). Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. JBIC. Journal of Biological Inorganic Chemistry (Print), v.20, p.1205-1217, 2015. http://doi.org/10.1007/s00775-015-1300-4

Scopus Q1, Impact Factor: 3,358.

Prieto, M.B., Georg, R.C., Gonzales-Zubiate, F.A., Luz, J.S., Oliveira, C.C. (2015). Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex. BMC Molecular Biology, v.16, p.1-14, 2015. http://doi.org/10.1186/s12867-015-0037-5   

Scopus Q2, Impact Factor: 2,946.

Gonzales, F.A., Saguez, C., Schmid, M., Boggild, A., Latrick, C.M., Malagon, F., Putnam, A., Sanderson, L., Jankowsky, E., Brodersen, D.E., Jensen, T.H. (2013). Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability. RNA (Cambridge. Print), v.19, p.1363-1371, 2013. http://doi.org/10.1261/rna.040048.113   

Scopus Q1, Impact Factor: 4,942.

Lee, Y-J., Lee, C.Y., Grzechnik, A., Gonzales-Zubiate, F.; Vashisht, A.A., Lee, A., Wohlschlegel, J., Chanfreau, G.F. (2013). RNA Polymerase I Stability Couples Cellular Growth to Metal Availability. Molecular Cell, v.51, p.105-115, 2013. https://doi.org/10.1016/j.molcel.2013.05.005   

Scopus Q1, Impact Factor: 19,328.

Gonzales, F.A., Singh, M., Cascio, D., Heckmann, N., Chanfreau, G., Feigon, J. (2008). Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1. Journal of Biological Chemistry, v.284, p.1906-1916, 2008. http://doi.org/10.1074/jbc.M807337200   

Scopus Q1, Impact Factor: 5,157.

Mitne-Neto, M., Ramos, C.R.R., Pimenta, D.C., Luz, J.S., Nishimura, A.L., Gonzales, F.A., Oliveira, C.C.; Zatz, M. (2007). A mutation in human VAP-B-MSP domain, present in ALS patients, affects the interaction with other cellular proteins. Protein Expression and Purification (Print), v.55, p.139-146, 2007. https://doi.org/10.1016/j.pep.2007.04.007   

Scopus Q2, Impact Factor: 1,650.

Luz, J.S., Tavares, J., Gonzales, F., Santos, M., Oliveira, C.C. (2007). Analysis of the Saccharomyces cerevisiae exosome architecture and of the RNA binding activity of Rrp40p. Biochimie (Paris. Print), v.89, p.686-691, 2007. https://doi.org/10.1016/j.biochi.2007.01.011   

Scopus Q1, Impact Factor: 4,079.

Granato, D.C., Gonzales, F.A., Luz, J.S., Cassiola, F., Machado-Santelli, G., Oliveira, C.C. (2005). Nop53p, an Essential Nucleolar Protein that Interacts with Nop17p and Nip7p, is Required for Pre-rRNA Processing in Saccharomyces cerevisiae. The FEBS Journal, v.272, p.4450-4463, 2005. https://doi.org/10.1111/j.1742-4658.2005.04861.x   

Scopus Q1, Impact Factor: 5,542.

Gonzales, F.A., Luz, J.S., Zanchin, N.I.T., Oliveira, C.C. (2005). Characterization of Saccharomyces cerevisiae Nop17p, a Novel Nop58p-Interacting Protein that is Involved in Pre-rRNA Processing. Journal of Molecular Biology, v.346, p.437-455, 2005. https://doi.org/10.1016/j.jmb.2004.11.071

Scopus Q1, Impact Factor: 5,469.

Oliveira, C.C., Gonzales, F.A., Zanchin, N.I.T. (2002). Temperature-sensitive mutants of the exosome subunit Rrp43p show mRNA degradation deficiency and no longer interact with the exosome. Nucleic Acids Research, v.30, p.4186-4198, 2002. https://doi.org/10.1093/nar/gkf545 

Scopus Q1, Impact Factor: 19,16.