Hortensia Rodriguez, Ph.D.


Hortensia M. Rodríguez obtained a B.Sc. in Radiochemistry from the Superior Institute of Science and Nuclear Technology (ISCTN, Cuba) (1991-1996). She then joined the Laboratory of Organic Synthesis of Faculty of Chemistry University of Havana (Cuba) and got a M.Sc. in 1999. In 2006 finished her Ph.D., focused on develop of non-conventional methods to the synthesis of bioactive heterocyclic compounds, which was awarded the best qualification (“Cum Laude”). Afterwards, she served as chair of the Laboratory of Organic Synthesis, as senior lecturer in the Chemistry Faculty of University of Havana (2006-2009), and as chair of the Department of Organic Chemistry in the Chemistry Faculty of the same university (2009-2011). Between 2011 and 2014 she worked as a Research Associate in the Chemistry and Molecular Pharmacology Program (Prof. Albericio group) at the Institute for Research in Biomedicine, Barcelona, Spain. At present, she is a Lecturer at YachayTech University, Ecuador. Her research covers a broad range of topics in synthetic bioorganic chemistry and nanobioscience.

Summary of Interests

Organic Synthesis focused on the Solid Phase Synthesis of small organic molecules and peptides. Greener synthetic approaches to biologically active chemical entities. Study of some organic systems under unconventional energies (microwave and ultrasound irradiation).Conjugation Techniques. Antibody Drug Conjugates as Drug Delivery Systems.

Current Research projects

Solid Phase Synthesis (Supports, linkers and/or methods)

Linkers for Antibody Drug Conjugates.

Supports for Mermbrane Enhanced Peptide Synthesis

Selected Publications

  • “CuAAC: An Efficient Click Chemistry Reaction on Solid Phase” V. Castro, H. Rodriguez, F. Albericio.  ACS Comb. Sci., 18, 1−14 (2016) DOI: 10.1021/acscombsci.5b00087.
  • “Tetrahydropyranyl, a Nonaromatic Acid-Labile Cys Protecting Group for Fmoc peptide Chemistry” I. Ramos-Tomillero, H. Rodríguez, F. Albericio. Org. Lett., 17, 7 (2015) DOI: 10.1021/acs.orglett.5b00444.
  • “Solvent-free synthesis of 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones under microwave irradiation.” H. Rodríguez, M. Suarez, R. Perez, A. Petit, A. Loupy. Tetrahedron Letters, 44, 3709 – 3712, (2003) DOI:10.1016/S0040-4039(03)00625-7


A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal


Journal: NATURAL PRODUCT RESEARCH Vol. 30(6), pp. 724-728

DOI: 10.1080/14786419.2015.1040791

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase


Journal: ACS COMBINATORIAL SCIENCE Vol. 18(1), pp. 1-14

DOI: 10.1021/acscombsci.5b00087

Tetrahydropyranyl, a Nonaromatic Acid-Labile Cys Protecting Group for Fmoc Peptide Chemistry


Journal: ORGANIC LETTERS, Vol. 17 (7), pp. 1680-1683

DOI: http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b00444